Incubator Accessories
Diagnostic Biosystems IRON STAIN Iron Stain
The Iron Stain Kit is intended for use in the detection of ferric iron in tissues, blood smears, or bone marrow smears. Ferric iron is normally found in small amounts in bone marrow and the spleen. Abnormally large deposits may be seen in hemochromatosis and hemosiderosis. This product is based on the Prussian Blue reaction in which ionic iron reacts with acid ferrocyanide producing a blue color.
Diagnostic Biosystems ELASTIN Elastin
This antibody recognizes insoluble elastin, α-elastin, soluble non-cross linked precursor of elastin (tropoelastin). Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues.
Diagnostic Biosystems LAMBDA LIGHT CHAIN-FITC Lambda Light Chain-FITC
Traces of contaminating antibodies have been removed by solid phase absorption. Only the lambda precipitation line appeared in cross immunoelectrophoresis. This antibody is well suited for tissue section staining but may also be used for other applications.
Diagnostic Biosystems NAPSIN A Napsin A
Napsin is found in two isoforms, A and B, with highly homologous gene sequences. Napsin A has a molecular weight of 35.0 kDa and is also known as TA02. Napsin A is an aspartic proteinase which is expressed in the lung and involved in processing surfactant protein B (SP-B). It is also expressed in the kidney. This antibody may be a useful tool as a tumor marker for primary lung adenocarcinoma. Napsin expression correlates with the differentiation grade of lung adenocarcinoma.
Diagnostic Biosystems PD-L1 PD-L1
The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.
Diagnostic Biosystems BCL-2 ONCOPROTEIN Bcl-2 Oncoprotein
This antibody recognizes a protein of 25-26kDa, identified as bcl-2 alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. This antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and small number in which neoplastic cells are bcl-2 negative.
Diagnostic Biosystems LBA1 Iba1 (AIF1)
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. AIF1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding AIF1 resides in the tumor necrosis factor (TNF) cluster of genes, located in the region represented by the human major histocompatibility complex (MHC).\n
Diagnostic Biosystems BAP1 BAP1 (BAP1/2667)
BAP1 (BRCA1-Associated Protein 1) was initially identified as a protein that binds to BRCA1. BAP1 is a tumor suppressor that is believed to mediate its effects through chromatin modulation, transcriptional regulation, and possibly via the ubiquitin-proteasome system and the DNA damage response pathway. Germline mutations of BAP1 confer increased susceptibility for the development of several tumors, including uveal melanoma, epithelioid atypical Spitz tumors, cutaneous melanoma, and mesothelioma. Somatic BAP1 mutations are seen in cutaneous melanocytic tumors (epithelioid atypical Spitztumors and melanoma), uveal melanoma, mesothelioma, clear cell renal cell carcinoma, and other tumors. BAP1 immunohistochemistry is particularly useful in differentiating malignant mesothelioma (nuclear negative) vs. reactive mesothelial proliferation (nuclear positive).
Diagnostic Biosystems CD4 CD4 (EP204)
CD4 is glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It is co-receptor that assists the T-cell receptor (TCR) with antigen-presenting cell and also interacts directly with MHC class II molecules of the surface of antigenpresenting cells. Most mature T-cell lymphomas are CD4 positive with the exception of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma. CD4 plays important role in the classification of lymphocytes in inflammatory legions and malignant lymphomas.
